My GF's work computer just got a particularly nasty piece of ransomware:

It has locked out task manager, system restore, and Superantispyware, spybot and malwarebytes could not remove it. The PC is running XP sp3 on a dell computer that's about 7ish years old. Her work is going to be getting new computers soon, but they want me to get this one running for the time being. I have also tried booting in safe mode, and it won't let me, this is literally the most stubborn virus I've gone up against and I'm running out of stuff to throw at it. If anyone has any ideas on how to remedy the problem any ideas are welcome. It's getting to the point that some data loss is acceptable.

Here is a Toyota for your time.