Yesterday I challenged oppo to come up with the largest cylinder differentials offered on one particular model of car at any one time. The highest we came up with was a difference of 8 cylinders.

From msatlas:

Yes, in 2011 you could get a 4-cylinder S250 CDI and a V12 S600.

From Ghost Dog:

Audi A8 (current Gen.) is available with a 2.0L 4 cylinder and a 6.3L W12. Does a hybrid count? Difference of 8 cylinders.

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From RamblinRover:

Can't believe I didn't think of this one earlier: late Cadillac V-16s (Series 90) were essentially altered versions of the Series 75's platform, which was a V8. That ties the S-class and Audi I4/V12 splits.

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Finally from me, Yowen:

The Mercedes SLS, avaliable with 0 cylinders (electric) and a V8